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KMID : 0369819950250020125
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Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 2 p.125 ~ p.128
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Effect of Fatty Alcohols on Skin Permeation of Flurbiprofen
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Abstract
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To increase the permeation rate of flurbiprofen, fatty alcohols were added in propylene glycol vehicle containing 1% flurbiprofen. Their enhancing effect on the skin permeation of flurbiprofen was evaluated using Keshary-Chien diffusion cells
fitted
with excised rat skins. Lauryl alcohol and oleyl alcohol increased the skin permeation rate of flurbiprofen 11.3 and 8.5 fold, respectively. compared to the control vehicle.
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